Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830985 | 0.95 | KMT2A (0.38) | ADRA2AADRA2BADRA2CADRA1ATRPV1 | |
| SCHEMBL2827049 | 0.90 | KMT2A (0.39) | ADRA2AADRA2BADRA2CADRA1AMAPT | |
| SCHEMBL2823459 | 0.85 | KDM4C (0.38) | PDE4BKDM4C | |
| SCHEMBL2828862 | 0.84 | KDM4C (0.38) | MAPTMEN1KMT2APDE4BKDM4C | |
| SCHEMBL2828338 | 0.82 | SMN1; SMN2 (0.41) | ADRA2AADRA2BADRA2CADRA1AMAPT | |
| SCHEMBL2825329 | 0.81 | PDE4B (0.40) | TRPV1L3MBTL1MEN1KMT2AALDH1A1 | |
| SCHEMBL1996275 | 0.81 | PDE4B (0.48) | ADRA2AADRA2BADRA2CADRA1AMAPT | |
| SCHEMBL2829802 | 0.80 | KMT2A (0.41) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL2828825 | 0.80 | KMT2A (0.40) | MAPTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL2826863 | 0.78 | ALDH1A1 (0.36) | MAPTL3MBTL1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |