Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | MARK3 | P27448 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828832 | 0.89 | PDE4B (0.43) | PDE4BRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2823459 | 0.85 | KDM4C (0.38) | PDE4BSMN1; SMN2ROCK2 | |
| SCHEMBL2828862 | 0.82 | KDM4C (0.38) | PDE4BMEN1KMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL2825199 | 0.81 | ADRA2A (0.40) | PDE4BMEN1KMT2ATRPV1ALDH1A1 | |
| SCHEMBL2828691 | 0.81 | PDE4B (0.42) | PDE4BRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2829191 | 0.74 | PDE4B (0.39) | PDE4BRAB9ANPC1MEN1KMT2A | |
| SCHEMBL2829407 | 0.74 | FPR2 (0.40) | PDE4BMEN1KMT2ATBXAS1SMN1; SMN2 | |
| SCHEMBL2825391 | 0.74 | KDM4C (0.40) | PDE4BSMN1; SMN2 | |
| SCHEMBL2829404 | 0.74 | PDE4B (0.39) | PDE4BNPC1MEN1KMT2ATBXAS1 | |
| SCHEMBL1993517 | 0.73 | PDE4B (0.46) | PDE4BRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |