Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 8/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 6/20 | 0.36 |
| ▸ | CES2 | O00748 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824055 | 0.87 | MLYCD (0.34) | FAAHCA12CA1CA9CES1 | |
| SCHEMBL25331966 | 0.79 | FAAH (0.38) | FAAHCA12CA1CA9CES1 | |
| SCHEMBL967486 | 0.78 | MLYCD (0.31) | — | |
| SCHEMBL27477241 | 0.75 | CA1 (0.36) | FAAHCA12CA1CA9CES1 | |
| SCHEMBL27770403 | 0.74 | — | — | |
| Trifluoroacetic Acid SCHEMBL28018017 | 0.71 | FAAH (0.38) | FAAHCA12CA1CA9CES1 | |
| SCHEMBL55496 | 0.70 | CA1 (0.56) | CA12CA1CA9CES1CES2 | |
| SCHEMBL20285412 | 0.70 | CA1 (0.44) | FAAHCA12CA1CA9CES1 | |
| SCHEMBL42636 | 0.70 | CA1 (0.56) | CA12CA1CA9CES1CES2 | |
| SCHEMBL7578456 | 0.69 | DNM1 (0.34) | FAAHCA12CA1CA9CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | disclosed |
| US-7511038-B2 | Pyridazin-3(2H)-one derivatives and their use as PDE4 inhibitors | LABORATORIOS ALMIRALL S.A. (ES) | 2009-03-31 | — | — | US | disclosed |
| EP-1575926-B1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL LAB (ES) | 2008-03-05 | — | — | EP | disclosed |