SCHEMBL28257971

SCHEMBL28257971

[CH2]N1CCN(Cc2cccc(N)c2F)CC1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.40
MPO P05164 1/20 0.40
CYP2A13 Q16696 1/20 0.38
KDM4E B2RXH2 6/20 0.38
LMNA P02545 2/20 0.38
HTT P42858 1/20 0.38
POLB P06746 3/20 0.37
GAA P10253 2/20 0.36
KMT2A Q03164 3/20 0.36
MEN1 O00255 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
ATM Q13315 1/20 0.36
MAPT P10636 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
AR P10275 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL247774 0.85 ALDH1A1 (0.56) ALDH1A1MPOCYP2A13KDM4EPOLB
SCHEMBL24113849 0.84 KDM4E (0.48) ALDH1A1MPOKDM4ELMNAPOLB
SCHEMBL10315553 0.83 ALDH1A1 (0.59) ALDH1A1KDM4ELMNAHTTPOLB
SCHEMBL23369636 0.83 ALDH1A1 (0.41) ALDH1A1MPOCYP2A13KDM4ELMNA
SCHEMBL21240868 0.82 ALDH1A1 (0.46) ALDH1A1KDM4ELMNAHTTPOLB
SCHEMBL16171454 0.81 HRH3 (0.49) ALDH1A1KDM4ELMNAHTTPOLB
SCHEMBL30543439 0.81 LMNA (0.51) ALDH1A1CYP2A13LMNAKMT2AMEN1
SCHEMBL249086 0.81 CYP2A13 (0.61) ALDH1A1CYP2A13KDM4ELMNAHTT
SCHEMBL8270669 0.78 CYP2A13 (0.37) ALDH1A1MPOCYP2A13KDM4ELMNA
SCHEMBL7859088 0.78 ALDH1A1 (0.53) ALDH1A1KDM4ELMNAHTTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108785265-A Heterocyclic compound and its purposes 美国安进公司 2018-11-13 CN disclosed