Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9542306 | 0.86 | KDM4E (0.41) | KDM4EMAPTCYP3A4ALOX15BCAT2 | |
| SCHEMBL6278245 | 0.77 | ALDH1A1 (0.49) | KDM4EMAPTCYP3A4ALOX15HPGD | |
| SCHEMBL28692019 | 0.75 | ALDH1A1 (0.44) | KDM4EMAPTCYP3A4ALOX15HPGD | |
| SCHEMBL29129651 | 0.74 | CTSD (0.41) | KDM4EMAPTCYP3A4ALOX15HPGD | |
| SCHEMBL5682092 | 0.73 | MAPT (0.39) | KDM4EMAPTCYP3A4ALOX15HPGD | |
| SCHEMBL24692389 | 0.73 | IRAK4 (0.44) | KDM4EMAPTCYP3A4IRAK4KEAP1 | |
| SCHEMBL27432511 | 0.73 | AKR1C3 (0.46) | KDM4EMAPTCYP3A4ALOX15HPGD | |
| SCHEMBL19437356 | 0.72 | CXCR2 (0.44) | KDM4EHPGDALDH1A1HSD17B10LMNA | |
| SCHEMBL19437462 | 0.72 | LMNA (0.44) | KDM4EMAPTCYP3A4ALOX15HPGD | |
| SCHEMBL3792769 | 0.72 | AKR1C3 (0.44) | KDM4EMAPTCYP3A4ALOX15ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884083-A | Benzo [ B ] furans as bromodomain inhibitors | 葛兰素史克知识产权第二有限公司 | 2018-11-23 | — | — | CN | disclosed |