Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2068873 | 0.80 | PPARD (0.48) | PPARG | |
| SCHEMBL2820978 | 0.77 | GRM5 (0.44) | GRM5NPC1RAB9APOLB | |
| SCHEMBL2069218 | 0.76 | PPARA (0.40) | GRM5ACACBPDE10AHAO1NPC1 | |
| SCHEMBL2068786 | 0.74 | PPARD (0.46) | PPARG | |
| SCHEMBL2821756 | 0.71 | GRM5 (0.41) | GRM5NPC1RAB9AMAPT | |
| SCHEMBL2827409 | 0.69 | GRM5 (0.47) | GRM5HAO1 | |
| SCHEMBL30278513 | 0.66 | GRM5 (0.68) | GRM5ACACBPDE10AKDM4EHAO1 | |
| SCHEMBL2822191 | 0.66 | GRM5 (0.43) | GRM5MAPTPPARGALDH1A1HPGD | |
| SCHEMBL6311520 | 0.65 | GRM5 (0.65) | GRM5ACACBPDE10AHAO1 | |
| SCHEMBL15870993 | 0.64 | GRM5 (0.68) | GRM5ACACBPDE10AHAO1FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745003-B1 | NOVEL COMPOUNDS, THEIR PREPARATION AND USE | HIGH POINT PHARMACEUTICALS LLC (US) | 2010-10-27 | — | — | EP | claimed |