SCHEMBL2827409 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	GRM5	P41594	4/20	0.47

▸	CA12	O43570	2/20	0.44

▸	CA1	P00915	2/20	0.44

▸	CA2	P00918	2/20	0.44

▸	CA9	Q16790	2/20	0.44

▸	FFAR1	O14842	1/20	0.40

▸	CHRM2	P08172	1/20	0.38

▸	CHRM1	P11229	1/20	0.38

▸	CHRM3	P20309	1/20	0.38

▸	MMP2	P08253	1/20	0.37

▸	MMP9	P14780	1/20	0.37

▸	HAO1	Q9UJM8	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2827415	0.85	GRM5 (0.44)	GRM5CA12CA1CA2CA9
SCHEMBL2068502	0.79	PPARD (0.53)	FFAR1
SCHEMBL2068483	0.76	MMP2 (0.41)	GRM5CA12CA1CA2CA9
SCHEMBL2820978	0.75	GRM5 (0.44)	GRM5
SCHEMBL6132140	0.72	GRM5 (0.66)	GRM5CA12CA1CA2CA9
SCHEMBL30707880	0.72	GRM5 (0.66)	GRM5CA12CA1CA2CA9
SCHEMBL2825829	0.69	GRM5 (0.43)	GRM5HAO1
SCHEMBL4267103	0.68	CA12 (0.63)	GRM5CA12CA1CA2CA9
SCHEMBL13335288	0.67	CA12 (0.62)	GRM5CA12CA1CA2CA9
SCHEMBL2825595	0.67	P4HB (0.36)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1745003-B1	NOVEL COMPOUNDS, THEIR PREPARATION AND USE	HIGH POINT PHARMACEUTICALS LLC (US)	2010-10-27	—	—	EP	claimed