Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.45 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5402590 | 0.93 | CRHBP (0.54) | CRHBPCRHR2ALDH1A1KDM4ELMNA | |
| SCHEMBL1133337 | 0.83 | CRHBP (0.53) | CRHBPCRHR2GABBR2GABBR1ALDH1A1 | |
| SCHEMBL27821076 | 0.83 | CRHBP (0.57) | CRHBPCRHR2GABBR2GABBR1ALDH1A1 | |
| SCHEMBL9875296 | 0.82 | CRHBP (0.60) | CRHBPCRHR2ALDH1A1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL1133335 | 0.81 | CRHBP (0.51) | CRHBPCRHR2GABBR2GABBR1ALDH1A1 | |
| SCHEMBL28087000 | 0.80 | CRHBP (0.51) | CRHBPCRHR2ALDH1A1KDM4ELMNA | |
| SCHEMBL5493235 | 0.80 | ALDH1A1 (0.46) | CRHBPCRHR2ALDH1A1KMT2AMTNR1A | |
| SCHEMBL28553963 | 0.79 | CRHBP (0.57) | CRHBPCRHR2ALDH1A1KDM4ELMNA | |
| SCHEMBL3320374 | 0.78 | HCAR2 (0.51) | ALDH1A1KDM4EKMT2AMTNR1AMTNR1B | |
| SCHEMBL8621149 | 0.78 | CRHBP (0.49) | CRHBPCRHR2ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109745321-A | Pharmaceutical composition comprising FGFR4 inhibitor | 上海翰森生物医药科技有限公司 | 2019-05-14 | — | — | CN | disclosed |
| CN-109071532-A | FGFR4 inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2018-12-21 | — | — | CN | disclosed |