Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.45 |
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828918 | 0.89 | GRM5 (0.44) | GRM5NAMPTTSHRLMNAPTBP1 | |
| SCHEMBL2825843 | 0.89 | GRM5 (0.58) | GRM5NAMPTSMN1; SMN2MEN1RAB9A | |
| SCHEMBL2827177 | 0.88 | ALDH1A1 (0.46) | GRM5LMNAALDH1A1GAAMEN1 | |
| SCHEMBL2832364 | 0.86 | GRM5 (0.55) | GRM5NAMPTRAB9A | |
| SCHEMBL2828432 | 0.86 | GRM5 (0.42) | GRM5NAMPTNOTUM | |
| SCHEMBL2829497 | 0.84 | LMNA (0.49) | GRM5LMNAHTTSMN1; SMN2NOTUM | |
| SCHEMBL2826008 | 0.84 | GRM5 (0.57) | GRM5LMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2829262 | 0.82 | GRM5 (0.44) | GRM5NAMPTLMNASMN1; SMN2 | |
| SCHEMBL2831112 | 0.80 | IRAK4 (0.46) | GRM5NAMPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL2830024 | 0.80 | ALDH1A1 (0.42) | GRM5LMNASMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |