Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826716 | 0.91 | GRM5 (0.50) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2830074 | 0.89 | CSNK2A1 (0.38) | GRM5CSNK2A1POLQ | |
| SCHEMBL2829701 | 0.87 | GRM5 (0.48) | GRM5PORCNPSEN1PSEN2APH1B | |
| SCHEMBL2829312 | 0.86 | GRM5 (0.52) | GRM5SMARCA2SMARCA4POLQPORCN | |
| SCHEMBL2826546 | 0.86 | GRM5 (0.46) | GRM5SMARCA2SMARCA4CSNK2A1PORCN | |
| SCHEMBL2828456 | 0.85 | GRM5 (0.45) | GRM5SMARCA2SMARCA4PORCNPSEN1 | |
| SCHEMBL2829553 | 0.84 | GRM5 (0.48) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2829130 | 0.84 | GRM5 (0.51) | GRM5SMARCA2SMARCA4PORCN | |
| SCHEMBL2831334 | 0.83 | GRM5 (0.54) | GRM5SMARCA2SMARCA4POLQPORCN | |
| SCHEMBL2830759 | 0.82 | SMARCA2 (0.43) | GRM5SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |