Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.52 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830286 | 0.88 | GRM5 (0.40) | GRM5POLQPIK3CGCDK4CDK2 | |
| SCHEMBL2829701 | 0.88 | GRM5 (0.48) | GRM5PORCNPSEN1PSEN2APH1B | |
| SCHEMBL2833088 | 0.88 | GRM5 (0.56) | GRM5PORCNSMARCA2SMARCA4HDAC3 | |
| SCHEMBL2829117 | 0.86 | GRM5 (0.38) | GRM5PIK3CGCDK4CDK2NPC1 | |
| SCHEMBL2826367 | 0.86 | GRM5 (0.44) | GRM5PORCNSMARCA2SMARCA4POLQ | |
| SCHEMBL2828456 | 0.86 | GRM5 (0.45) | GRM5PORCNSMARCA2SMARCA4PSEN1 | |
| SCHEMBL2826318 | 0.86 | GRM5 (0.54) | GRM5PORCNSMARCA2SMARCA4NPC1 | |
| SCHEMBL2831334 | 0.86 | GRM5 (0.54) | GRM5PORCNSMARCA2SMARCA4POLQ | |
| SCHEMBL2833093 | 0.86 | GRM5 (0.69) | GRM5PORCNSMARCA2SMARCA4HDAC3 | |
| SCHEMBL2831342 | 0.85 | GRM5 (0.53) | GRM5PORCNSMARCA2SMARCA4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |