Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.36 |
| ▸ | KDR | P35968 | 4/20 | 0.36 |
| ▸ | RET | P07949 | 4/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | LTK | P29376 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | CDK7 | P50613 | 2/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737965 | 0.84 | KDM4E (0.34) | LRRK2KDRRETDAPK3MAP4K4 | |
| SCHEMBL678617 | 0.84 | EGFR (0.36) | LRRK2KDRRETDAPK3MAP4K4 | |
| SCHEMBL11115133 | 0.84 | KDR (0.35) | LRRK2KDRRETDAPK3MAP4K4 | |
| SCHEMBL14467430 | 0.79 | EGFR (0.32) | KDREGFRABL1PIK3CDHCK | |
| SCHEMBL12891981 | 0.72 | PI4KA (0.34) | LRRK2KDRRETDAPK3MAP4K4 | |
| SCHEMBL4734704 | 0.72 | EGFR (0.58) | LRRK2DAPK3MAP4K4CSNK1A1RPS6KA3 | |
| SCHEMBL1094820 | 0.71 | EGFR (0.48) | KDRRETEGFRABL1LMNA | |
| SCHEMBL3889725 | 0.71 | HTR2C (0.47) | FLT3RPS6KB1 | |
| SCHEMBL1703145 | 0.70 | — | — | |
| SCHEMBL8131114 | 0.70 | NOS2 (0.37) | CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332859-B | Hydrazone compound and preparation method and application thereof | 华中师范大学 | 2025-02-25 | — | — | CN | disclosed |
| CN-116332859-A | Hydrazone compound and preparation method and application thereof | 华中师范大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-109020957-B | Heterocyclic compounds as MNK inhibitors | 南京天印健华医药科技有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-20220289719-A1 | HETEROCYCLIC COMPOUNDS AS MNK INHIBITORS | NANJING INNOCARE PHARMA TECH CO., LTD. (CN) | 2022-09-15 | — | — | US | disclosed |
| CN-109020957-A | Heterocyclic compound as MNK inhibitor | 南京天印健华医药科技有限公司 | 2018-12-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220289719-A1 | HETEROCYCLIC COMPOUNDS AS MNK INHIBITORS | NIM1K, MAP3K1, MAPKAPK2 | LRRK2 487/4885KDR 2645/4885RET 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.