SCHEMBL28264384

SCHEMBL28264384

O=CC1C=Cc2ccccc2N1OC(F)F

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
P2RX4 Q99571 2/20 0.33
P2RX1 P51575 1/20 0.33
P2RX3 P56373 1/20 0.33
P2RX7 Q99572 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
ALDH1A1 P00352 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
LMNA P02545 1/20 0.32
MAPK1 P28482 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31067284 0.71 MEN1 (0.40) P2RX4P2RX1P2RX3P2RX7SMN1; SMN2
SCHEMBL5796284 0.71 MEN1 (0.40) P2RX4P2RX1P2RX3P2RX7SMN1; SMN2
SCHEMBL29276948 0.58 MEN1 (0.43) P2RX4P2RX1P2RX3P2RX7SMN1; SMN2
SCHEMBL5174448 0.58 MEN1 (0.36) P2RX4P2RX1P2RX3P2RX7SMN1; SMN2
SCHEMBL8911614 0.56 LMNA (0.47) P2RX4P2RX1P2RX3P2RX7SMN1; SMN2
SCHEMBL7697985 0.56 SMN1; SMN2 (0.59) P2RX4P2RX1P2RX3P2RX7SMN1; SMN2
SCHEMBL19261265 0.55 SMN1; SMN2 (0.37) P2RX4P2RX1P2RX3P2RX7SMN1; SMN2
SCHEMBL7528727 0.55 SMN1; SMN2 (0.46) P2RX4P2RX1P2RX3P2RX7SMN1; SMN2
SCHEMBL7000034 0.55 SMN1; SMN2 (0.59) P2RX4P2RX1P2RX3P2RX7SMN1; SMN2
SCHEMBL63929 0.54 HTR2A (0.34) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109121397-A Heterocyclic compound, especially 2- oxo -4,4,5,5,6,6,7,7- octahydro benzoxazoles derivatives and their purposes as antimicrobial compound 莱德克斯制药公共有限公司 2019-01-01 CN disclosed