Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | FABP3 | P05413 | 1/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.40 |
| ▸ | CTSA | P10619 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825663 | 0.89 | KMT2A (0.41) | FABP3FABP4NR1H2CTSAHTT | |
| SCHEMBL2821965 | 0.88 | FABP3 (0.39) | FABP3FABP4CTSAHTTKDM4E | |
| SCHEMBL2822034 | 0.82 | FABP3 (0.53) | GAAMAPTNPSR1FABP3FABP4 | |
| SCHEMBL2824267 | 0.81 | ALDH1A1 (0.48) | GAAMAPTNPSR1FABP3FABP4 | |
| SCHEMBL2825609 | 0.80 | SMN1; SMN2 (0.44) | GAAMAPTNPSR1FABP3FABP4 | |
| SCHEMBL2824685 | 0.79 | KDM4E (0.41) | MAPTNPSR1FABP3FABP4NR1H2 | |
| SCHEMBL2824278 | 0.78 | MRGPRX1 (0.38) | HTT | |
| SCHEMBL2824252 | 0.78 | FABP3 (0.38) | GAAMAPTNPSR1FABP3FABP4 | |
| SCHEMBL2824206 | 0.76 | DHODH (0.37) | NR1H2NR1H3PTGDR2 | |
| SCHEMBL1125943 | 0.75 | GAA (0.64) | GAAMAPTNPSR1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |