Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824252 | 0.90 | FABP3 (0.38) | KDM4EALDH1A1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL2824267 | 0.90 | ALDH1A1 (0.48) | KDM4EALDH1A1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL2825663 | 0.89 | KMT2A (0.41) | KDM4EALDH1A1KMT2AFABP3FABP4 | |
| SCHEMBL2824278 | 0.89 | MRGPRX1 (0.38) | ALDH1A1HTTCYP2C9POLB | |
| SCHEMBL2823538 | 0.83 | FABP3 (0.44) | KDM4EALDH1A1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL2823282 | 0.81 | ENPP1 (0.39) | KDM4EALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2821965 | 0.80 | FABP3 (0.39) | KDM4EKMT2ASMN1; SMN2FABP3FABP4 | |
| SCHEMBL2825609 | 0.80 | SMN1; SMN2 (0.44) | KDM4EALDH1A1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL2826082 | 0.79 | ENPP1 (0.43) | KDM4EALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2826445 | 0.79 | GAA (0.48) | KDM4EKMT2ASMN1; SMN2MEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809605-B1 | QUINOLINES AS ALLOSTERIC ENHANCERS OF THE GABA-B RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |