Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828787 | 0.89 | MAPT (0.47) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2828557 | 0.89 | KDM4E (0.43) | ALDH1A1MAPK1FLT1KDRSMN1; SMN2 | |
| SCHEMBL2829103 | 0.85 | SMN1; SMN2 (0.47) | ALDH1A1FLT1KDRSMN1; SMN2MEN1 | |
| SCHEMBL2830832 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPK1FAAHCYP3A4FLT1 | |
| SCHEMBL2827571 | 0.82 | LMNA (0.47) | ALDH1A1MAPK1FAAHCYP3A4FLT1 | |
| SCHEMBL2832974 | 0.81 | ALDH1A1 (0.52) | ALDH1A1MAPK1FAAHCYP3A4FLT1 | |
| SCHEMBL2830984 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPK1FAAHCYP3A4FLT1 | |
| SCHEMBL2830799 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPK1FAAHCYP3A4FLT1 | |
| SCHEMBL2828940 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MAPK1FAAHCYP3A4FLT1 | |
| SCHEMBL2826937 | 0.78 | ALDH1A1 (0.48) | ALDH1A1MAPK1FAAHCYP3A4FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |