Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 8/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826318 | 0.93 | GRM5 (0.54) | GRM5SMARCA2SMARCA4NPC1CASP3 | |
| SCHEMBL2829033 | 0.90 | GRM5 (0.44) | GRM5SMARCA2SMARCA4 | |
| SCHEMBL2831187 | 0.90 | GRM5 (0.57) | GRM5SMARCA2SMARCA4NPC1CASP3 | |
| SCHEMBL2828939 | 0.90 | SMARCA2 (0.48) | GRM5SMARCA2SMARCA4NPC1CASP3 | |
| SCHEMBL2827196 | 0.88 | GRM5 (0.58) | GRM5SMARCA2SMARCA4NPC1PIK3CA | |
| SCHEMBL2826248 | 0.86 | SMARCA2 (0.56) | GRM5SMARCA2SMARCA4NPC1CASP3 | |
| SCHEMBL2827812 | 0.85 | SMARCA2 (0.46) | GRM5SMARCA2SMARCA4NPC1CASP3 | |
| SCHEMBL2827277 | 0.84 | JAK2 (0.44) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL2830759 | 0.84 | SMARCA2 (0.43) | GRM5SMARCA2SMARCA4NPC1CASP3 | |
| SCHEMBL2824786 | 0.84 | GRM5 (0.46) | GRM5SMARCA2SMARCA4NPC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |