Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 9/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 8/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831334 | 0.91 | GRM5 (0.54) | GRM5SMARCA2SMARCA4CYP1A2CYP3A4 | |
| SCHEMBL2826560 | 0.90 | GRM5 (0.46) | GRM5SMARCA2SMARCA4 | |
| SCHEMBL2830759 | 0.90 | SMARCA2 (0.43) | GRM5SMARCA2SMARCA4AR | |
| SCHEMBL2831187 | 0.88 | GRM5 (0.57) | GRM5SMARCA2SMARCA4 | |
| SCHEMBL2824786 | 0.88 | GRM5 (0.46) | GRM5SMARCA2SMARCA4AR | |
| SCHEMBL2828939 | 0.88 | SMARCA2 (0.48) | GRM5SMARCA2SMARCA4 | |
| SCHEMBL2827196 | 0.87 | GRM5 (0.58) | GRM5SMARCA2SMARCA4 | |
| SCHEMBL2826248 | 0.84 | SMARCA2 (0.56) | GRM5SMARCA2SMARCA4 | |
| SCHEMBL2826318 | 0.84 | GRM5 (0.54) | GRM5SMARCA2SMARCA4 | |
| SCHEMBL2827812 | 0.84 | SMARCA2 (0.46) | GRM5SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |