Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.58 |
| ▸ | SMARCA2 | P51531 | 4/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.41 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826714 | 0.91 | GRM5 (0.70) | GRM5SMARCA2SMARCA4PORCNJAK2 | |
| SCHEMBL2831187 | 0.90 | GRM5 (0.57) | GRM5SMARCA2SMARCA4NPC1 | |
| SCHEMBL2828939 | 0.90 | SMARCA2 (0.48) | GRM5SMARCA2SMARCA4PORCNNPC1 | |
| SCHEMBL2826781 | 0.89 | GRM5 (0.52) | GRM5NPC1MEN1KMT2ACYP11B2 | |
| SCHEMBL2826560 | 0.88 | GRM5 (0.46) | GRM5SMARCA2SMARCA4NPC1PIK3CA | |
| SCHEMBL2827009 | 0.87 | GRM5 (0.53) | GRM5NPC1KMT2AJAK2JAK3 | |
| SCHEMBL2829033 | 0.87 | GRM5 (0.44) | GRM5SMARCA2SMARCA4 | |
| SCHEMBL2827277 | 0.86 | JAK2 (0.44) | GRM5SMARCA2SMARCA4NPC1MEN1 | |
| SCHEMBL2826248 | 0.86 | SMARCA2 (0.56) | GRM5SMARCA2SMARCA4PORCNNPC1 | |
| SCHEMBL2828233 | 0.85 | SMARCA2 (0.42) | GRM5SMARCA2SMARCA4PORCNNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |