Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 9/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 8/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830759 | 0.92 | SMARCA2 (0.43) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL2828939 | 0.92 | SMARCA2 (0.48) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL2829033 | 0.88 | GRM5 (0.44) | GRM5SMARCA2SMARCA4AR | |
| SCHEMBL2826248 | 0.88 | SMARCA2 (0.56) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL2831187 | 0.86 | GRM5 (0.57) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL2826560 | 0.84 | GRM5 (0.46) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL2827196 | 0.84 | GRM5 (0.58) | GRM5SMARCA2SMARCA4NPC1 | |
| SCHEMBL2827812 | 0.83 | SMARCA2 (0.46) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL2829478 | 0.83 | SMARCA2 (0.53) | GRM5SMARCA2SMARCA4NPC1RAB9A | |
| SCHEMBL2826716 | 0.82 | GRM5 (0.50) | GRM5SMARCA2SMARCA4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |