Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827507 | 0.78 | TSHR (0.42) | TSHRGAAALDH1A1HTTUSP2 | |
| SCHEMBL2827508 | 0.78 | TSHR (0.42) | TSHRGAAALDH1A1HTTUSP2 | |
| SCHEMBL233175 | 0.78 | HSD11B1 (0.53) | TSHRGAAALDH1A1HTTUSP2 | |
| SCHEMBL2023571 | 0.78 | HSD11B1 (0.53) | TSHRGAAALDH1A1HTTUSP2 | |
| SCHEMBL2827513 | 0.78 | TSHR (0.42) | TSHRGAAALDH1A1HTTUSP2 | |
| SCHEMBL2826753 | 0.78 | HSD11B1 (0.41) | TSHRLMNACYP2D6CYP1A2 | |
| SCHEMBL2823718 | 0.72 | HSD11B1 (0.53) | — | |
| SCHEMBL2831194 | 0.70 | HSD11B1 (0.36) | — | |
| SCHEMBL6336040 | 0.68 | TSHR (0.56) | TSHRGAAALDH1A1HTTUSP2 | |
| SCHEMBL4721495 | 0.67 | ALDH1A1 (0.67) | TSHRGAAALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |