Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823718 | 0.78 | HSD11B1 (0.53) | HSD11B1 | |
| SCHEMBL2826625 | 0.78 | TSHR (0.40) | LMNACYP1A2CYP2D6TSHR | |
| SCHEMBL2822075 | 0.77 | HSD11B1 (0.44) | HSD11B1GRIN2BGRIN1 | |
| SCHEMBL2822073 | 0.77 | HSD11B1 (0.44) | HSD11B1GRIN2BGRIN1 | |
| SCHEMBL2822076 | 0.76 | HSD11B1 (0.41) | HSD11B1GRIN2BADRA2AHTR2AADRA1A | |
| SCHEMBL231438 | 0.76 | HSD11B1 (0.61) | HSD11B1GRIN2BGRIN1KCNH2 | |
| SCHEMBL2831194 | 0.72 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL2827581 | 0.69 | HSD11B1 (0.40) | HSD11B1 | |
| SCHEMBL2053950 | 0.68 | HSD11B1 (0.50) | HSD11B1GRIN2BGRIN1KCNH2 | |
| SCHEMBL2830144 | 0.67 | HSD11B1 (0.33) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |