Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL5968326 | 0.93 | ALDH1A1 (0.57) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA | |
| Pyridine SCHEMBL20958 | 0.92 | ALDH1A1 (0.58) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA | |
| Pyridine SCHEMBL2126952 | 0.92 | ALDH1A1 (0.58) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA | |
| Pyridine SCHEMBL6427981 | 0.92 | ALDH1A1 (0.58) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA | |
| Pyridine SCHEMBL31483849 | 0.92 | ALDH1A1 (0.58) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA | |
| Pyridine SCHEMBL7656088 | 0.92 | ALDH1A1 (0.58) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA | |
| Pyridine SCHEMBL3261023 | 0.92 | ALDH1A1 (0.58) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA | |
| Pyridine SCHEMBL28538739 | 0.90 | ALDH1A1 (0.57) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA | |
| Pyridine SCHEMBL28166378 | 0.90 | ALDH1A1 (0.57) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA | |
| Pyridine SCHEMBL28981792 | 0.90 | ALDH1A1 (0.57) | ALDH1A1MAPTTDP1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109254106-A | A kind of method of quality control of Pitavastatin Calcium side chain | 迪沙药业集团（天津）药物研究有限公司 | 2019-01-22 | — | — | CN | claimed |
| CN-109254106-A | A kind of method of quality control of Pitavastatin Calcium side chain | 迪沙药业集团（天津）药物研究有限公司 | 2019-01-22 | — | — | CN | disclosed |