Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Fluorescein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 8/20 | 0.89 |
| ▸ | MAPT | P10636 | 4/20 | 0.89 |
| ▸ | MEN1 | O00255 | 4/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.89 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.89 |
| ▸ | HTT | P42858 | 2/20 | 0.89 |
| ▸ | HPGD | P15428 | 2/20 | 0.89 |
| ▸ | RECQL | P46063 | 2/20 | 0.89 |
| ▸ | BLM | P54132 | 2/20 | 0.89 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.89 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.89 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.89 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.89 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorescein SCHEMBL9844354 | 1.00 | FTO (0.89) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL5872682 | 1.00 | FTO (0.89) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL21638746 | 0.95 | FTO (0.85) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL29371199 | 0.94 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL30272223 | 0.94 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL3645090 | 0.94 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL16533 | 0.94 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL29388667 | 0.94 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL7519170 | 0.93 | FTO (0.87) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL3459138 | 0.93 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105861492-B | A kind of rapidly extracting and evaluation method of Apoptosis high quality small fragment DNA | 四川农业大学 | 2019-01-29 | — | — | CN | disclosed |