SCHEMBL28274128

SCHEMBL28274128

Cc1ccc(CC(F)(F)c2ccccc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 7/20 0.45
MEN1 O00255 4/20 0.45
KMT2A Q03164 4/20 0.45
LMNA P02545 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
POLB P06746 2/20 0.42
ALDH1A1 P00352 2/20 0.42
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
TSHR P16473 2/20 0.39
PTPN5 P54829 1/20 0.39
HRH1 P35367 1/20 0.39
XBP1 P17861 1/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ALOX12 P18054 1/20 0.39
ACHE P22303 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7776137 0.85 CYP1A2 (0.54) KIF11LMNASMN1; SMN2ALDH1A1CYP1A2
SCHEMBL6682555 0.78 KIF11 (0.50) KIF11MEN1KMT2ALMNAPOLB
SCHEMBL29271946 0.76 KIF11 (0.45) KIF11MEN1KMT2ALMNASMN1; SMN2
SCHEMBL3217541 0.74 KIF11 (0.44) KIF11MEN1KMT2ALMNASMN1; SMN2
SCHEMBL8853831 0.74 KIF11 (0.44) KIF11MEN1KMT2ALMNASMN1; SMN2
SCHEMBL2008110 0.74 KIF11 (0.44) KIF11MEN1KMT2ALMNASMN1; SMN2
SCHEMBL1821550 0.73 IDO1 (0.46) CYP1A2TSHRACHE
SCHEMBL19451469 0.73 IDO1 (0.46) CYP1A2TSHRACHE
SCHEMBL10360564 0.73 KIF11 (0.43) KIF11MEN1KMT2ALMNASMN1; SMN2
SCHEMBL27590092 0.73 KIF11 (0.46) KIF11MEN1KMT2ALMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109293692-B Gem-difluoroalkyl borate compounds and preparation method and application thereof 中山大学 2021-05-11 CN disclosed
CN-109293692-A One kind is together with fluoroalkyl boric acid ester compound and its preparation method and application 中山大学 2019-02-01 CN disclosed