Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827440 | 0.90 | GRM5 (0.46) | GRM5KDRCHRNA7RAB9ASMN1; SMN2 | |
| SCHEMBL2828398 | 0.84 | GRM5 (0.47) | GRM5RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL2833093 | 0.82 | GRM5 (0.69) | GRM5KMT2AMEN1 | |
| SCHEMBL2831187 | 0.82 | GRM5 (0.57) | GRM5RAB9ANPC1 | |
| SCHEMBL2826336 | 0.80 | GRM5 (0.70) | GRM5RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2829267 | 0.77 | GRM5 (0.55) | GRM5RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL2826292 | 0.77 | GRM5 (0.44) | GRM5 | |
| SCHEMBL2830257 | 0.76 | GRM5 (0.50) | GRM5MAPTKMT2A | |
| SCHEMBL2829877 | 0.76 | GRM5 (0.45) | GRM5KMT2AMEN1ALDH1A1 | |
| SCHEMBL2828771 | 0.76 | GRM5 (0.55) | GRM5RAB9AKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |