Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826781 | 0.91 | GRM5 (0.52) | GRM5MAPTLMNANPC1KMT2A | |
| SCHEMBL2832150 | 0.89 | KMT2A (0.50) | GRM5MAPTLMNAHTTNPC1 | |
| SCHEMBL2827550 | 0.87 | BRAF (0.48) | MAPTLMNAHTTNPC1RAB9A | |
| SCHEMBL2827440 | 0.86 | GRM5 (0.46) | GRM5MAPTLMNAHTTNPC1 | |
| SCHEMBL2825999 | 0.86 | LMNA (0.41) | GRM5MAPTLMNAHTTNPC1 | |
| SCHEMBL2831187 | 0.86 | GRM5 (0.57) | GRM5NPC1RAB9A | |
| SCHEMBL2829877 | 0.84 | GRM5 (0.45) | GRM5GAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL2824920 | 0.84 | ABL1 (0.45) | GRM5MAPTLMNAHTTNPC1 | |
| SCHEMBL2830402 | 0.84 | MAPT (0.45) | MAPTLMNAHTTNPC1RAB9A | |
| SCHEMBL2827540 | 0.84 | GRM5 (0.47) | GRM5MAPTNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |