Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | GBA1 | P04062 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829877 | 0.91 | GRM5 (0.45) | GRM5CYP1A2CYP2C9CYP3A4KMT2A | |
| SCHEMBL2824785 | 0.90 | GRM5 (0.70) | GRM5RAB9ANPC1GBA1KMT2A | |
| SCHEMBL2828397 | 0.88 | GRM5 (0.58) | GRM5CYP1A2CYP2C9CYP3A4 | |
| SCHEMBL2828101 | 0.85 | GRM5 (0.48) | GRM5RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2828771 | 0.84 | GRM5 (0.55) | GRM5RAB9ANPC1KMT2A | |
| SCHEMBL2830257 | 0.84 | GRM5 (0.50) | GRM5CYP1A2KMT2AMAPT | |
| SCHEMBL2830253 | 0.83 | GRM5 (0.51) | GRM5RAB9ANPC1KMT2A | |
| SCHEMBL2826292 | 0.83 | GRM5 (0.44) | GRM5 | |
| SCHEMBL2826109 | 0.83 | GRM5 (0.47) | GRM5RAB9ANPC1GBA1KMT2A | |
| SCHEMBL2826581 | 0.82 | GRM5 (0.50) | GRM5RAB9ANPC1GBA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |