Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | IL1B | P01584 | 1/20 | 0.30 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829034 | 0.89 | GRM5 (0.71) | GRM5HSD17B10 | |
| SCHEMBL2829267 | 0.84 | GRM5 (0.55) | GRM5NPC1RAB9AKMT2A | |
| SCHEMBL2830257 | 0.83 | GRM5 (0.50) | GRM5NTRK1KMT2A | |
| SCHEMBL2829877 | 0.83 | GRM5 (0.45) | GRM5KMT2A | |
| SCHEMBL2826336 | 0.82 | GRM5 (0.70) | GRM5NPC1RAB9A | |
| SCHEMBL2826292 | 0.82 | GRM5 (0.44) | GRM5NTRK1 | |
| SCHEMBL2828397 | 0.81 | GRM5 (0.58) | GRM5NTRK1 | |
| SCHEMBL2827806 | 0.80 | GRM5 (0.44) | GRM5NTRK1NPC1RAB9A | |
| SCHEMBL2833093 | 0.77 | GRM5 (0.69) | GRM5KMT2A | |
| SCHEMBL2830798 | 0.77 | GRM5 (0.44) | GRM5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |