Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826591 | 0.89 | GRM5 (0.46) | GRM5RAB9AKMT2ANPC1JAK2 | |
| SCHEMBL2824785 | 0.86 | GRM5 (0.70) | GRM5RAB9AKMT2ANPC1JAK2 | |
| SCHEMBL2826109 | 0.85 | GRM5 (0.47) | GRM5RAB9AKMT2ANPC1 | |
| SCHEMBL2826581 | 0.85 | GRM5 (0.50) | GRM5RAB9AKMT2ANPC1JAK2 | |
| SCHEMBL2830506 | 0.83 | GRM5 (0.48) | GRM5RAB9AKMT2ANPC1JAK2 | |
| SCHEMBL2829267 | 0.83 | GRM5 (0.55) | GRM5RAB9AKMT2ANPC1 | |
| SCHEMBL2832964 | 0.83 | GRM5 (0.52) | GRM5KMT2AJAK2 | |
| SCHEMBL2827599 | 0.82 | GRM5 (0.46) | GRM5RAB9AKMT2ANPC1 | |
| SCHEMBL2827277 | 0.80 | JAK2 (0.44) | GRM5RAB9AKMT2ANPC1JAK2 | |
| SCHEMBL2828101 | 0.77 | GRM5 (0.48) | GRM5RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |