Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826109 | 0.90 | GRM5 (0.47) | GRM5RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL2830253 | 0.89 | GRM5 (0.51) | GRM5RAB9AJAK2NPC1KMT2A | |
| SCHEMBL2827599 | 0.86 | GRM5 (0.46) | GRM5RAB9ANPC1KMT2ANTRK1 | |
| SCHEMBL2830506 | 0.86 | GRM5 (0.48) | GRM5RAB9AJAK2NPC1KMT2A | |
| SCHEMBL2828477 | 0.84 | NPC1 (0.44) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2824785 | 0.82 | GRM5 (0.70) | GRM5RAB9AJAK2JAK3NPC1 | |
| SCHEMBL2829267 | 0.82 | GRM5 (0.55) | GRM5RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL2826581 | 0.81 | GRM5 (0.50) | GRM5RAB9AJAK2NPC1KMT2A | |
| SCHEMBL2829478 | 0.81 | SMARCA2 (0.53) | GRM5RAB9AJAK2JAK3NPC1 | |
| SCHEMBL2827914 | 0.79 | GRM5 (0.47) | GRM5RAB9AJAK2NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |