Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | APLNR | P35414 | 1/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856167 | 0.87 | TP53 (0.69) | TP53GAAALDH1A1APLNRCYP19A1 | |
| SCHEMBL12982388 | 0.86 | TP53 (0.68) | TP53GAAALDH1A1APLNRCYP19A1 | |
| SCHEMBL29668784 | 0.86 | TP53 (0.61) | TP53GAAALDH1A1APLNRCYP19A1 | |
| SCHEMBL29250014 | 0.86 | TP53 (0.67) | TP53GAAAPLNRLMNACYP3A4 | |
| SCHEMBL29660937 | 0.84 | GAA (0.72) | GAAALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4661701 | 0.84 | GAA (0.72) | GAAALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL12494016 | 0.82 | ALDH1A1 (0.62) | TP53GAAALDH1A1APLNRKMT2A | |
| SCHEMBL2856162 | 0.82 | TP53 (0.59) | TP53GAAALDH1A1APLNRKMT2A | |
| SCHEMBL28211731 | 0.82 | MEN1 (0.63) | TP53GAAALDH1A1CYP19A1KMT2A | |
| SCHEMBL22353139 | 0.82 | TP53 (0.56) | TP53GAAALDH1A1APLNRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116462662-A | Aromatic ring Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2023-07-21 | — | — | CN | disclosed |
| CN-109415321-B | Aromatic sulfonamide derivatives | 拜耳制药股份公司 | 2022-06-17 | — | — | CN | disclosed |
| CN-114591293-A | Fused ring compound as Nav1.8 inhibitor and application thereof | 成都康弘药业集团股份有限公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-109415321-A | aromatic sulfonamide derivatives | 拜耳制药股份公司 | 2019-03-01 | — | — | CN | disclosed |