Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.44 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28281841 | 0.85 | DHFR (0.49) | DHFRLCKKITSRCADORA2A | |
| SCHEMBL28281757 | 0.81 | NFKB1 (0.38) | DHFRABL1LCKKITSRC | |
| SCHEMBL1643374 | 0.80 | DHFR (0.49) | DHFRADORA2AADORA1CYP1A2XDH | |
| SCHEMBL25272927 | 0.79 | CYP1A2 (0.45) | DHFRPI4KBCYP1A2HPGDCYP3A4 | |
| SCHEMBL22513570 | 0.76 | GSR (0.57) | CYP1A2ALOX5PTGS1PTGS2NPC1 | |
| SCHEMBL428127 | 0.74 | ADORA2A (0.49) | DHFRADORA2AADORA1PIK3CAMTOR | |
| SCHEMBL6683210 | 0.74 | CACNA1D (0.48) | DHFRPIK3CAMTORPIK3CDPIK3C2A | |
| SCHEMBL17439972 | 0.73 | MTOR (0.52) | DHFRLCKSRCPIK3CAMTOR | |
| SCHEMBL426847 | 0.72 | HCAR1 (0.48) | DHFRPIK3CAMTORPIK3CDCYP1A2 | |
| SCHEMBL9955061 | 0.68 | PIK3CG (0.48) | LCKSRCPIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476696-A | Anti-trypanosome and anti-leishmania agents for animals and humans | 细胞基因公司 | 2019-03-15 | — | — | CN | claimed |
| CN-109476696-A | Anti-trypanosome and anti-leishmania agents for animals and humans | 细胞基因公司 | 2019-03-15 | — | — | CN | disclosed |