Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amineptine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amineptine SCHEMBL5783484 | 0.81 | HTR2C (1.00) | SLC6A3HTR2COPRM1DRD3NR1I2 | |
| Amineptine SCHEMBL29389410 | 0.81 | HTR2C (1.00) | SLC6A3HTR2COPRM1DRD3NR1I2 | |
| Amineptine SCHEMBL34086 | 0.81 | HTR2C (1.00) | SLC6A3HTR2COPRM1DRD3NR1I2 | |
| Amineptine SCHEMBL340428 | 0.79 | HTR2C (0.97) | SLC6A3HTR2COPRM1DRD3NR1I2 | |
| Amineptine SCHEMBL362962 | 0.79 | HTR2C (0.97) | SLC6A3HTR2COPRM1DRD3NR1I2 | |
| Quinupramine SCHEMBL29985275 | 0.74 | CHRM2 (1.00) | SLC6A3CHRM2CHRM1OPRM1DRD3 | |
| Quinupramine SCHEMBL366044 | 0.74 | CHRM2 (1.00) | SLC6A3CHRM2CHRM1OPRM1DRD3 | |
| Quinupramine SCHEMBL49100 | 0.74 | CHRM2 (1.00) | SLC6A3CHRM2CHRM1OPRM1DRD3 | |
| SCHEMBL28969679 | 0.67 | HTR2C (0.72) | SLC6A3HTR2COPRM1DRD3NR1I2 | |
| SCHEMBL19197798 | 0.67 | NR1I2 (0.80) | SLC6A3HTR2COPRM1DRD3NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003212-A | A3 adenosine receptor agonist | 美国卫生和人力服务部 | 2019-07-12 | — | — | CN | disclosed |
| CN-105934433-B | A3 adenosine receptor agonists | 美国卫生和人力服务部 | 2019-03-22 | — | — | CN | disclosed |