Quinupramine

Quinupramine

SCHEMBL29985275

c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 3/20 1.00
CHRM1 P11229 3/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
DRD1 P21728 1/20 1.00
SLC6A2 P23975 1/20 1.00
SLC6A4 P31645 1/20 1.00
ADRA1A P35348 1/20 1.00
OPRM1 P35372 1/20 1.00
DRD3 P35462 1/20 1.00
SLC6A3 Q01959 1/20 1.00
KCNH2 Q12809 1/20 1.00
CHRM3 P20309 2/20 0.43
CHRM4 P08173 1/20 0.43
CHRM5 P08912 1/20 0.43
CHRNA7 P36544 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinupramine SCHEMBL366044 1.00 CHRM2 (1.00) CHRM2CHRM1HTR1AADRA2ADRD1
Quinupramine SCHEMBL49100 1.00 CHRM2 (1.00) CHRM2CHRM1HTR1AADRA2ADRD1
Quinupramine SCHEMBL13280380 0.82 SLC6A4 (0.67) CHRM2CHRM1HTR1AADRA2ADRD1
SCHEMBL13471233 0.80 CHRM2 (0.66) CHRM2CHRM1HTR1AADRA2ADRD1
SCHEMBL13471238 0.80 ADRA2A (0.66) CHRM2CHRM1HTR1AADRA2ADRD1
SCHEMBL20216589 0.80 CHRM2 (0.66) CHRM2CHRM1HTR1AADRA2ADRD1
Amineptine SCHEMBL28280844 0.74 SLC6A3 (0.65) CHRM2CHRM1HTR1AADRA2ADRD1
SCHEMBL7281251 0.71 CHRM2 (0.55) CHRM2CHRM1HTR1AADRA2ADRD1
SCHEMBL7290543 0.71 CHRM2 (0.55) CHRM2CHRM1HTR1AADRA2ADRD1
SCHEMBL24903369 0.68 SLC18A3 (0.53) CHRM2CHRM1HTR1AADRA2ADRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3706762-B1 N4-HYDROXYCYTIDINE DERIVATIVE AND ANTI-VIRAL USES RELATED THERETO UNIV EMORY (US) 2024-10-16 EP claimed
WO-2022198003-A1 NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 2 VANDERBILT UNIVERSITY (US) 2022-09-22 WO disclosed