Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 3/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15650038 | 0.78 | ALDH1A1 (0.44) | TSHRMAPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2830535 | 0.78 | PPARA (0.48) | TSHRMAPK1PPARGLMNAALDH1A1 | |
| SCHEMBL22347377 | 0.78 | ALDH1A1 (0.41) | MAPK1PPARGLMNAALDH1A1DRD2 | |
| SCHEMBL18405594 | 0.77 | CA4 (0.39) | CA4LTA4HTSHRKCNA3MAPK1 | |
| SCHEMBL3365142 | 0.77 | CA4 (0.39) | CA4LTA4HTSHRMAPK1PPARG | |
| SCHEMBL826787 | 0.77 | KMT2A (0.54) | — | |
| SCHEMBL31285836 | 0.76 | LTA4H (0.39) | CA4LTA4HTSHRKCNA3LMNA | |
| SCHEMBL5722454 | 0.74 | CA4 (0.41) | CA4LTA4HTSHRLMNAALDH1A1 | |
| SCHEMBL11641137 | 0.74 | PPARA (0.44) | LTA4HTSHRMAPK1PPARGLMNA | |
| SCHEMBL3717182 | 0.73 | CA4 (0.43) | CA4LTA4HTSHRKCNA3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125862-A1 | PROCESSES FOR THE PREPARATION OF ZANUBRUTINIB AND INTERMEDIATES THEREOF | TEVA PHARMACEUTICALS INTERNATIONAL GMBH (CH) | 2022-06-16 | — | — | WO | disclosed |
| CN-103772239-B | amide and amidine derivatives and uses thereof | ABBVIE 公司 | 2017-04-12 | — | — | CN | disclosed |
| CN-102459158-B | Novel amide and amidine derivatives and use thereof | ABBVIE (US) | 2015-11-25 | — | — | CN | disclosed |
| CN-103772239-A | Novel amide and amidine derivatives and uses thereof | ABBVIE INC | 2014-05-07 | — | — | CN | disclosed |
| US-8507493-B2 | Amide and amidine derivatives and uses thereof | ABBVIE INC. (US) | 2013-08-13 | — | — | US | disclosed |
| CN-102459158-A | Novel amide and amidine derivatives and use thereof | ABBOTT LAB | 2012-05-16 | — | — | CN | disclosed |
| WO-2010123838-A2 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |
| EP-2243479-A2 | Novel amide and amidine derivates and uses thereof | Abbott Laboratories (US) | 2010-10-27 | — | — | EP | disclosed |
| US-20100267738-A1 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | ABBOTT LABORATORIES (US) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267738-A1 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | HSD11B2, HSD11B1, HSD17B2 | CA4 4459/4885LTA4H 820/4885TSHR 1055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.