Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5676 | 0.84 | — | — | |
| SCHEMBL244401 | 0.81 | — | — | |
| Pyridine SCHEMBL4577146 | 0.79 | TSHR (0.56) | NAPRTTDP1TSHRKDM4ECYP2A6 | |
| Pyridine SCHEMBL10951607 | 0.78 | TSHR (0.64) | NAPRTTDP1TSHRLMNACYP1A2 | |
| Bicarbonate SCHEMBL2178826 | 0.77 | NAPRT (0.48) | NAPRTTDP1TSHRLMNAP4HTM | |
| Pyridine SCHEMBL28482158 | 0.75 | TDP1 (0.60) | NAPRTTDP1TSHRNOS3NOS1 | |
| Benzene SCHEMBL10751789 | 0.73 | TSHR (1.00) | NAPRTTDP1TSHRLMNACYP1A2 | |
| Pyridine SCHEMBL933604 | 0.73 | TSHR (1.00) | NAPRTTDP1TSHRLMNACYP1A2 | |
| Pyridine SCHEMBL9037865 | 0.73 | TSHR (1.00) | NAPRTTDP1TSHRLMNACYP1A2 | |
| Pyridine SCHEMBL1654468 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107286134-B | 2,4- disubstituted pyrimidines derivatives are as CDK inhibitor and its application | 上海勋和医药科技有限公司 | 2019-04-12 | — | — | CN | disclosed |