Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28126198 | 0.82 | GPR119 (0.49) | GPR119KDM4EGAATSHRHSD17B10 | |
| SCHEMBL28282171 | 0.81 | PIK3CA (0.34) | GPR119GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL27726923 | 0.76 | CHRNB4 (0.38) | GPR119KMT2APOLB | |
| SCHEMBL27786683 | 0.74 | HRH3 (0.35) | HSD17B10MAPTMEN1KMT2AHPGD | |
| SCHEMBL27726935 | 0.72 | SPHK1 (0.47) | KDM4ETSHRMEN1KMT2APOLB | |
| SCHEMBL30445218 | 0.71 | LMNA (0.41) | KDM4ETSHRHSD17B10MAPTGABRA1 | |
| SCHEMBL4730546 | 0.70 | GPR119 (0.65) | GPR119KDM4ETSHRMAPTMEN1 | |
| SCHEMBL10209181 | 0.70 | SMN1; SMN2 (0.46) | GPR119KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL10209180 | 0.68 | SMN1; SMN2 (0.47) | GPR119KDM4ETSHRGABRA1GABRG2 | |
| SCHEMBL428908 | 0.68 | HRH3 (0.37) | TSHRMEN1KMT2AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106588885-B | 2- replaces aromatic ring-pyridine derivatives and preparation and application | 浙江大学 | 2019-03-19 | — | — | CN | disclosed |