Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 7/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 6/20 | 0.42 |
| ▸ | GRM5 | P41594 | 3/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 4/20 | 0.36 |
| ▸ | BCR | P11274 | 3/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830413 | 0.91 | GRM5 (0.51) | SMARCA2SMARCA4GRM5ABL1BCR | |
| SCHEMBL2824920 | 0.88 | ABL1 (0.45) | GRM5ABL1BCRNPC1RAB9A | |
| SCHEMBL2828939 | 0.87 | SMARCA2 (0.48) | SMARCA2SMARCA4GRM5MAPK3PORCN | |
| SCHEMBL2827196 | 0.85 | GRM5 (0.58) | SMARCA2SMARCA4GRM5ABL1PORCN | |
| SCHEMBL2827277 | 0.85 | JAK2 (0.44) | SMARCA2SMARCA4GRM5NPC1RAB9A | |
| SCHEMBL2831187 | 0.85 | GRM5 (0.57) | SMARCA2SMARCA4GRM5NPC1CASP3 | |
| SCHEMBL2830047 | 0.83 | SMARCA2 (0.41) | SMARCA2SMARCA4GRM5MAPK3PORCN | |
| SCHEMBL2826560 | 0.83 | GRM5 (0.46) | SMARCA2SMARCA4GRM5NPC1CASP3 | |
| SCHEMBL2826248 | 0.83 | SMARCA2 (0.56) | SMARCA2SMARCA4GRM5PORCNNPC1 | |
| SCHEMBL2829033 | 0.82 | GRM5 (0.44) | SMARCA2SMARCA4GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |