Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | SYK | P43405 | 6/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | CDK4 | P11802 | 3/20 | 0.49 |
| ▸ | CCND1 | P24385 | 3/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28870899 | 0.93 | JAK3 (0.53) | JAK3JAK2SYKJAK1CDK2 | |
| SCHEMBL4584445 | 0.83 | MAPT (0.55) | SYKKDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL22609596 | 0.82 | MAPT (0.54) | SYKKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3718998 | 0.81 | MAPT (0.52) | JAK3JAK2SYKJAK1KDM4E | |
| SCHEMBL2718370 | 0.81 | SYK (0.53) | JAK2SYKKDM4EALDH1A1HPGD | |
| SCHEMBL28282980 | 0.78 | MAPK8 (0.52) | SYKKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3638560 | 0.77 | MAPK1 (0.50) | JAK3JAK2SYKJAK1KDM4E | |
| SCHEMBL31403002 | 0.77 | JAK3 (0.49) | JAK3JAK2JAK1CDK2CDK1 | |
| SCHEMBL31582419 | 0.77 | PARP1 (0.42) | JAK3JAK2SYKJAK1KDM4E | |
| SCHEMBL28321809 | 0.77 | SYK (0.44) | SYKKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106061967-B | The nicotinamide compounds replaced through heteroaryl | 百时美施贵宝公司 | 2019-04-19 | — | — | CN | claimed |