Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828381 | 0.90 | KMT2A (0.37) | PDE4BKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2828403 | 0.89 | KMT2A (0.48) | MAPTL3MBTL1MEN1KMT2APKM | |
| SCHEMBL2828825 | 0.88 | KMT2A (0.40) | PDE4BKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2828338 | 0.87 | SMN1; SMN2 (0.41) | PDE4BKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2829418 | 0.85 | MAPT (0.40) | PDE4BKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2828388 | 0.85 | PDE4B (0.39) | PDE4BALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2828384 | 0.84 | SMN1; SMN2 (0.38) | PDE4BKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2828404 | 0.83 | LMNA (0.44) | KDM4EALDH1A1MEN1KMT2APKM | |
| SCHEMBL2829802 | 0.83 | KMT2A (0.41) | PDE4BKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2828838 | 0.83 | SMN1; SMN2 (0.35) | PDE4BKDM4EALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |