Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.39 |
| ▸ | PDE4A | P27815 | 3/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826007 | 0.89 | KDM4C (0.35) | PDE4BPDE4APDE4CPDE4DCYP1A2 | |
| SCHEMBL2828120 | 0.88 | KDM4C (0.38) | PDE4BPDE4APDE4CPDE4DCYP1A2 | |
| SCHEMBL2828005 | 0.85 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL2829340 | 0.85 | KDM4C (0.41) | PDE4BPDE4APDE4CPDE4DCYP1A2 | |
| SCHEMBL2829346 | 0.82 | KDM4C (0.36) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL2828108 | 0.80 | KDM4C (0.41) | PDE4BPDE4APDE4CPDE4DKDM4C | |
| SCHEMBL2829015 | 0.80 | ALDH1A1 (0.46) | GAAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1997196 | 0.79 | PDE4B (0.34) | PDE4BPDE4APDE4CPDE4DCYP1A2 | |
| SCHEMBL2828114 | 0.79 | ROCK2 (0.39) | KDM4CKMT2AALDH1A1 | |
| SCHEMBL2826438 | 0.79 | GPR52 (0.39) | KDM4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-B1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | ALMIRALL SA (ES) | 2010-12-22 | — | — | EP | claimed |