Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830277 | 0.91 | MAPT (0.42) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL2828966 | 0.90 | GRM5 (0.40) | MAPTKDM4EALDH1A1LMNANHERF1 | |
| SCHEMBL2827550 | 0.87 | BRAF (0.48) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL2826783 | 0.87 | GRM5 (0.49) | MAPTALDH1A1LMNAMAPK1PDK1 | |
| SCHEMBL2832150 | 0.85 | KMT2A (0.50) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL2827914 | 0.84 | GRM5 (0.47) | LMNANPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2828398 | 0.84 | GRM5 (0.47) | MAPTKDM4EALDH1A1LMNAHTT | |
| SCHEMBL2826781 | 0.83 | GRM5 (0.52) | MAPTALDH1A1LMNANPC1KMT2A | |
| SCHEMBL2832757 | 0.83 | CA2 (0.45) | MAPTL3MBTL1KMT2AMEN1POLB | |
| SCHEMBL2829284 | 0.81 | NPC1 (0.41) | KDM4EALDH1A1LMNAHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |