Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.44 |
| ▸ | RAB9A | P51151 | 10/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828836 | 0.87 | NPC1 (0.42) | NPC1RAB9ATRPV4MAPTMEN1 | |
| SCHEMBL2828127 | 0.85 | SMARCA2 (0.42) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL2826591 | 0.84 | GRM5 (0.46) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL2828434 | 0.82 | MAPT (0.50) | NPC1RAB9ATRPV4MAPTMEN1 | |
| SCHEMBL2828219 | 0.82 | SMARCA2 (0.49) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL2827578 | 0.81 | GRM5 (0.50) | NPC1RAB9ATRPV4MAPTSMN1; SMN2 | |
| SCHEMBL2827951 | 0.81 | NPC1 (0.41) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL2830868 | 0.80 | MAPT (0.46) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL2828924 | 0.80 | SMARCA2 (0.61) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL2829478 | 0.79 | SMARCA2 (0.53) | NPC1RAB9AMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |