Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 11/20 | 0.44 |
| ▸ | NPC1 | O15118 | 10/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828836 | 0.83 | NPC1 (0.42) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2828434 | 0.83 | MAPT (0.50) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2831340 | 0.83 | NPC1 (0.47) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2830798 | 0.83 | GRM5 (0.44) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2829129 | 0.82 | GRM5 (0.41) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2824734 | 0.81 | RAB9A (0.46) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2828219 | 0.80 | SMARCA2 (0.49) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2828477 | 0.80 | NPC1 (0.44) | MAPTRAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL2825830 | 0.80 | RAB9A (0.44) | MAPTRAB9ANPC1SMN1; SMN2GLA | |
| SCHEMBL2830051 | 0.80 | RAB9A (0.40) | MAPTRAB9ANPC1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |