Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 5/20 | 0.53 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2828939 | 0.88 | SMARCA2 (0.48) | SMARCA2SMARCA4JAK2JAK1TYK2 | |
| SCHEMBL2827277 | 0.87 | JAK2 (0.44) | SMARCA2SMARCA4JAK2JAK1TYK2 | |
| SCHEMBL2830047 | 0.85 | SMARCA2 (0.41) | SMARCA2SMARCA4JAK2JAK1TYK2 | |
| SCHEMBL2826248 | 0.85 | SMARCA2 (0.56) | SMARCA2SMARCA4JAK2JAK1TYK2 | |
| SCHEMBL2827196 | 0.83 | GRM5 (0.58) | SMARCA2SMARCA4JAK2NPC1JAK3 | |
| SCHEMBL2831187 | 0.83 | GRM5 (0.57) | SMARCA2SMARCA4NPC1RAB9AGRM5 | |
| SCHEMBL2824786 | 0.83 | GRM5 (0.46) | SMARCA2SMARCA4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2830759 | 0.83 | SMARCA2 (0.43) | SMARCA2SMARCA4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2826591 | 0.81 | GRM5 (0.46) | JAK2NPC1RAB9AMAPTJAK3 | |
| SCHEMBL2826560 | 0.81 | GRM5 (0.46) | SMARCA2SMARCA4NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |