Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825247 | 0.96 | NPC1 (0.44) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL2831135 | 0.88 | NPC1 (0.51) | NPC1RAB9AKMT2ASMN1; SMN2MAPT | |
| SCHEMBL2828420 | 0.87 | GRK2 (0.44) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2829443 | 0.87 | MEN1 (0.50) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2830068 | 0.87 | SMN1; SMN2 (0.44) | RAB9AMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL2832981 | 0.86 | EPHX2 (0.52) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2826937 | 0.84 | ALDH1A1 (0.48) | NPC1RAB9AKMT2AGAASMN1; SMN2 | |
| SCHEMBL2829765 | 0.83 | KMT2A (0.43) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL2826660 | 0.83 | LMNA (0.46) | NPC1RAB9AMEN1KMT2AGAA | |
| SCHEMBL2830000 | 0.82 | NPC1 (0.47) | NPC1RAB9AMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |