Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2832981 | 0.99 | EPHX2 (0.52) | MEN1KMT2AEPHX2LMNANPC1 | |
| SCHEMBL2826660 | 0.96 | LMNA (0.46) | MEN1KMT2AEPHX2LMNANPC1 | |
| SCHEMBL2831135 | 0.88 | NPC1 (0.51) | KMT2ANPC1RAB9ACYP3A4MAPT | |
| SCHEMBL2828482 | 0.87 | NPC1 (0.50) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL2828420 | 0.87 | GRK2 (0.44) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL2830068 | 0.87 | SMN1; SMN2 (0.44) | MEN1KMT2AEPHX2LMNARAB9A | |
| SCHEMBL2826937 | 0.84 | ALDH1A1 (0.48) | KMT2ANPC1RAB9ACYP3A4HPGD | |
| SCHEMBL2830058 | 0.83 | LMNA (0.50) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL2829765 | 0.83 | KMT2A (0.43) | MEN1KMT2ALMNANPC1RAB9A | |
| SCHEMBL2825247 | 0.83 | NPC1 (0.44) | MEN1KMT2ALMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |