Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EYA3 | Q99504 | 4/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.57 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29464057 | 1.00 | EYA3 (0.65) | EYA3PTPN1HTTLMNASLC22A12 | |
| SCHEMBL9486589 | 0.93 | HTT (0.60) | EYA3PTPN1HTTLMNASLC22A12 | |
| SCHEMBL15362406 | 0.91 | EYA3 (0.53) | EYA3PTPN1HTTLMNASLC22A12 | |
| SCHEMBL12964086 | 0.90 | EYA3 (0.52) | EYA3PTPN1HTTLMNASLC22A12 | |
| SCHEMBL446008 | 0.90 | EYA3 (0.52) | EYA3PTPN1HTTLMNASLC22A12 | |
| SCHEMBL4891172 | 0.90 | EYA3 (0.57) | EYA3PTPN1HTTLMNATTR | |
| SCHEMBL12074785 | 0.89 | EYA3 (0.51) | EYA3PTPN1HTTLMNASLC22A12 | |
| SCHEMBL5711188 | 0.89 | SLC22A12 (0.73) | EYA3PTPN1HTTLMNASLC22A12 | |
| SCHEMBL4567254 | 0.89 | KDM5A (0.58) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL283212 | 0.89 | MAPK1 (0.60) | EYA3PTPN1HTTSLC22A12CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 318 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115385880-A | Industrial preparation method of environment-friendly dronedarone key intermediate | 南京方生和医药科技有限公司 | 2022-11-25 | — | — | CN | claimed |
| CN-109970693-A | A kind of preparation method of dronedarone key intermediate | 南京方生和医药科技有限公司 | 2019-07-05 | — | — | CN | claimed |
| CN-105753822-B | A kind of benzofuran derivative, its preparation method and application | 华润赛科药业有限责任公司 | 2018-04-03 | — | — | CN | claimed |
| CN-106892886-A | A kind of preparation method of dronedarone hydrochloride | 上海华源医药科技发展有限公司 | 2017-06-27 | — | — | CN | claimed |
| CN-105753822-A | Benzofuran derivative and preparation method and application thereof | 华润赛科药业有限责任公司 | 2016-07-13 | — | — | CN | claimed |
| EP-2417099-B1 | NEW PROCESS FOR PREPARING HYDROXYLAMINES AND MEDICAMENTS | CAMBREX KARLSKOGA AB (SE) | 2015-12-23 | — | — | EP | claimed |
| CN-102459154-B | For the preparation of the novel method of azanol class and medicine | CAMBREX KARLSKOGA AB (SE) | 2015-12-02 | — | — | CN | claimed |
| EP-2388256-B1 | Process for preparing benzofurans | CAMBREX KARLSKOGA AB (SE) | 2015-11-25 | — | — | EP | claimed |
| CN-105061369-A | Related substance F of dronedarone hydrochloride and preparation method for related substance F | NANJING CHIA TAI TIANQING PHARMACEUTICAL CO LTD | 2015-11-18 | — | — | CN | claimed |
| CN-102171200-B | For the preparation of the method for diones and medicine | CAMBREX KARLSKOGA AB (SE) | 2015-09-30 | — | — | CN | claimed |
| CN-102171200-A | New process for preparing diketones and medicaments | CAMBREX KARLSKOGA AB | 2011-08-31 | — | — | CN | claimed |
| CN-102153530-A | Novel method for synthesizing dronedarone key intermediate | BEIJING ORGGREEN CHEMISTRY TECHNOLOGY CO LTD | 2011-08-17 | — | — | CN | claimed |
| EP-2356100-A1 | NEW PROCESS FOR PREPARING DIKETONES AND MEDICAMENTS | Cambrex Karlskoga AB (SE) | 2011-08-17 | — | — | EP | claimed |
| CN-101948455-A | Preparation method of 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran | SHANDONG ZOUPING DAZHAN NEW MATERIAL CO LTD | 2011-01-19 | — | — | CN | claimed |
| US-20100292319-A1 | PROCESS FOR PREPARING BENZOFURANS | CAMBREX KARLSKOGA AB (SE) | 2010-11-18 | — | — | US | claimed |
| WO-2010116140-A1 | NEW PROCESS FOR PREPARING HYDROXYLAMINES AND MEDICAMENTS | CAMBREX KARLSKOGA AB (SE) | 2010-10-14 | — | — | WO | claimed |
| CN-101861308-A | Process for the preparation of benzofuran compounds | CAMBREX KARLSKOGA AB | 2010-10-13 | — | — | CN | claimed |
| EP-2200993-A2 | PROCESS FOR PREPARING BENZOFURANS | Cambrex Karlskoga AB (SE) | 2010-06-30 | — | — | EP | claimed |
| WO-2010038029-A1 | NEW PROCESS FOR PREPARING DIKETONES AND MEDICAMENTS | CAMBREX KARLSKOGA AB (SE) | 2010-04-08 | — | — | WO | claimed |
| WO-2009044143-A2 | PROCESS FOR PREPARING BENZOFURANS | CAMBREX KARLSKOGA AB (SE) | 2009-04-09 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292319-A1 | PROCESS FOR PREPARING BENZOFURANS | CYP2F1, CYP3A4, CYP4F3 | EYA3 4548/4885PTPN1 4513/4885HTT 2787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.