SCHEMBL28290037

SCHEMBL28290037

COc1ccc(N(C)C(=O)C#Cc2ccccc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.57
KMT2A Q03164 2/20 0.56
MEN1 O00255 1/20 0.56
NPC1 O15118 1/20 0.56
POLB P06746 1/20 0.56
RAB9A P51151 1/20 0.56
NLRP3 Q96P20 1/20 0.56
APP P05067 1/20 0.43
LMNA P02545 3/20 0.43
MAPT P10636 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HPGD P15428 2/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 3/20 0.43
HTT P42858 2/20 0.43
CYP3A4 P08684 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
ALOX12 P18054 1/20 0.43
CES2 O00748 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25918159 0.86 NPSR1 (0.70) NPSR1KMT2AMEN1NPC1POLB
SCHEMBL28291465 0.86 NPSR1 (0.54) NPSR1NPC1POLBRAB9ALMNA
SCHEMBL28290036 0.82 NPSR1 (0.60) NPSR1KMT2AMEN1NPC1POLB
SCHEMBL28291463 0.82 NPSR1 (0.60) NPSR1NPC1POLBRAB9AAPP
SCHEMBL23953228 0.82 MEN1 (0.44) NPSR1KMT2AMEN1NPC1POLB
SCHEMBL22080043 0.81 KMT2A (0.54) NPSR1KMT2AMEN1NPC1POLB
SCHEMBL3859101 0.79 MCHR1 (0.53) NPSR1KMT2AMEN1NLRP3MAPT
SCHEMBL3861889 0.79 MCHR1 (0.64) CYP3A4CYP1A2
SCHEMBL6241316 0.78 NPC1 (0.65) NPSR1KMT2AMEN1NPC1POLB
SCHEMBL22079525 0.77 NPSR1 (0.57) NPSR1KMT2AMEN1NPC1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107337663-B A kind of preparation method of thio three ketene compound of loop coil of visible light-inducing 3- 曲阜师范大学 2019-09-17 CN disclosed
CN-107141248-B A kind of method of visible light catalytic synthesis three ketene compound of 3- sulfuryl loop coil 曲阜师范大学 2019-04-30 CN disclosed